Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors
نویسندگان
چکیده
منابع مشابه
Atg8 Family Proteins — Autophagy and Beyond
In eukaryotic cells, macroautophagy is now recognised as the most important mechanism for degradation of long-lived proteins and complete organelles, thus enabling cells to sustain their function under conditions of stress, such as nutrient deprivation, hypoxia or the presence of intracellular pathogens (for recent reviews, see [1,2]). While the core machinery is conserved in all eukaroytes [3]...
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Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are localized to the membrane in an ubiquitin-like conjugation reaction, but how this conjugation is coupled to the presence of the cargo is unclear. Here we show that the S. cerevisiae Atg19, Atg34 and the human p62, Optineurin and NDP52 cargo rece...
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Selective autophagy contributes to cellular homeostasis by delivering harmful material into the lysosomal system for degradation via vesicular intermediates referred to as autophagosomes. The cytoplasm-to-vacuole targeting pathway is a variant of selective autophagy in Saccharomyces cerevisiae during which hydrolases such as prApe1 are transported into the vacuole. In general, selectivity is ac...
متن کاملLC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy
Autophagy protects cellular homeostasis by capturing cytosolic components and invading pathogens for lysosomal degradation. Autophagy receptors target cargo to autophagy by binding ATG8 on autophagosomal membranes. The expansion of the ATG8 family in higher eukaryotes suggests that specific interactions with autophagy receptors facilitate differential cargo handling. However, selective interact...
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Macroautophagy/autophagy has been shown to mediate the selective lysosomal degradation of pathogenic bacteria and viruses (xenophagy), and to contribute to the activation of innate and adaptative immune responses. Autophagy can serve as an antiviral defense mechanism but also as a proviral process during infection. Atg8-family proteins play a central role in the autophagy process due to their a...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2020
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2019.07.016